Emerging diagnostic and therapeutic technologies based on ultrasound-triggered biomaterials

Abstract Ultrasound (US) is a kind of acoustic wave with frequency higher than 20 kHz. Learning from the echo detection ability bats and dolphins, scientists applied US for clinical imaging by sending out waves detecting echoes shifted intensities frequencies human tissue. has long played critical role in noninvasive, real-time, low-cost portable diagnostic imaging. With in-depth study multidisciplinary fields, US-responsive materials have shown practical value not only disease diagnosis, but also treatment. In this review, we introduce recently proposed representative biomedical applications, including therapeutic applications. We focused on US-mediated physicochemical therapies, such as sonodynamic therapy, high-intensity ablation, sonothermal thrombolysis, etc, US-controlled delivery chemotherapeutics, gases, genes, proteins bacteria. conclude current challenges facing translation smart prospects future development medicine.